2022

Targeting acetylcholine signaling modulates persistent drug tolerance in EGFR-mutant lung cancer and impedes tumor relapse

Authors: Nie M#, Chen N#, Pang H#, Jiang T#, [...], DeBerardinis RJ, Li W, Yu Q, Zhou C, Hu ZP*

Periodical: Journal of Clinical Investigation(2022) (PDF)

Cancer associated fibroblasts employ NUFIP1-dependent autophagy to secrete nucleosides and support pancreatic tumor growth

Authors: Yuan M, Tu B, Li H, Pang H,[...], Ying H, Zhu WG, Fu D, Hu ZP*, Zhao Y*

Periodical: Nature Cancer(2022) (PDF)

Treatment of SARS-CoV-2 induced pneumonia with NAD+ and NMN in two mouse models

Authors: Jiang Y*,#, Deng Y#, Pang H#, Ma T, Ye Q, Chen Q, Chen H, Hu ZP*, Qin CF*, Xu Z*

Periodical: Cell Discovery(2022) (PDF)

Metabolic characterization of hypertrophic cardiomyopathy in human hearts

Authors: Wang W#, Wang J#,*, Yao K#, Wang S#, Nie M,[...], Yang T, Li P, Song L*, Hu ZP*

Periodical: Nature Cardiovascular Research(2022) (PDF)

Circulatory metabolites trigger ex vivo arterial endothelial cell dysfunction in population chronically

Authors: Cheng W#, Pang H#,[...], Leng S*, Hu ZP*, Tang J*

Periodical: Particle and Fibre Toxicology(2022) (PDF)

2021

Metabolic remodelling during early mouse embryo development

Authors: Jing Zhao#,Ke Yao#,Ling Z#,Yuyan X#,[...],Zeping H*, Jin Zhang*

Periodical: Nature Metabolism(2021) (PDF)

Aberrant NAD+ metabolism underlies ZIKA virus-induced microcephaly

Authors: Pang H#, Jiang Y#, Li J#, Wang Y#, Nie M#, Xiao N, Wang S, Song Z, Ji F, Chang Y, Zheng Y, Yao K, Yao L, Li S, Song L*, Lan X*, Xu Z*, Hu Z*

Periodical: Nature Metabolism(2021) (PDF)

Simultaneous 3-Nitrophenylhydrazine Derivatization Strategy of Carbonyl, Carboxyl and Phosphoryl Submetabolome for LC-MS/MS-Based Targeted Metabolomics with Improved Sensitivity and Coverage

Authors: Meng X#, Pang H#, Sun F, Jin X, Wang B, Yao K, Yao L, Wang L, Liao M, Hu Z*

Periodical: Analytical Chemistry(2021) (PDF)

Integrated cytokine and metabolite analysis reveals immunometabolic reprogramming in COVID-19 patients with therapeutic implications

Authors: Xiao N#, Nie M#, Pang H#, Wang B#, Hu J#, Meng X, Li K, Ran X, Long Q, Deng H, Li S, Chen N, Li S, Tang N*, Huang A*, Hu Z*

Periodical: Nature Communications(2021) (PDF)

Metabolomics, metabolic flux analysis and cancer pharmacology

Authors: Liang L, Sun F, Wang H, Hu Z*

Periodical: Pharmacology & Therapeutics(2021) (PDF)

2019

Mettl17, a regulator of mitochondrial ribosomal RNA modifications, is required for the translation of mitochondrial coding genes

Authors: Shi Z, Xu S, Xing S, Yao K, Zhang L, Xue L, Zhou P, Wang M, Yan G, Yang P, Liu J, Hu Z*, Lan F*

Periodical: The FASEB Journal(2019) (PDF)

Emerging applications of metabolomics in clinical pharmacology

Authors: Pang H, Jia W*, Hu Z*

Periodical: Clinical Pharmacology and Therapeutics(2019) (PDF)

Recent applications of metabolic flux analysis in tumor metabolism

Authors: Li Wen-jie, Hu ze-ping*

Periodical: Chinese Journal of the Frontiers of Medical Science(2019) (PDF)

Metabolic reprogramming and cancer drug resistance

Authors: Yao Li-ang, Hu ze-ping*

Periodical: Chinese Journal of the Frontiers of Medical Science(2019) (PDF)

2018

Arginine deficiency is involved in thrombocytopenia and immunosuppression in Severe Fever with Thrombocytopenia Syndrome

Authors: Li XK, Lu QB, Chen WW, Xu W, Liu R, Zhang SF, Du J, Li H, Yao K,[...],Cao WC*, Hu Z*, Liu W*

Periodical: Science Translational Medicine(2018) (PDF)

Inosine monophosphate dehydrogenase dependence in a subset of small cell lung cancers

Authors: Huang F, Ni M, Chalishazar MD, Huffman KE, Kim J, Cai L, Shi X, Cai F, Zacharias LG, Ireland AS, Li K, Gu W, Kaushik AK, Liu X, Gazdar AF, Oliver TG, Minna JD, Hu Z*, DeBerardinis RJ*

Periodical: Cell Metabolism(2018) (PDF)

2017

Ascorbate regulates haematopoietic stem cell function and suppresses leukaemogenesis

Authors: Agathocleous M, Meacham C, Burgess RJ, Piskounova E, Bruner E, Cowin B, Crane GM, Murphy MM, Hu Z, DeBerardinis RJ, Morrison SJ

Periodical: Nature(2017) (PDF)

CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells

Authors: Kim J, Hu Z, Cai L, Choi E, Rodriguez-Canales J, Villalobos P, Lin YF, Ni M, Unsal-Kacmaz K, Peña CG, Castrillon DH, Chen BPC, Wistuba I, Minna JD, DeBerardinis RJ

Periodical: Nature(2017) (PDF)

Hypoxia induces heart regeneration in adult mice

Authors: Nakada Y, Canseco DC, Thet S, Abdisalaam S, Asaithamby A, Santos CX, Shah A, Zhang H, Faber JE, Kinter MT, Szweda LI, Xing C, Hu Z, Deberardinis RJ, Schiattarella G, Hill JA, Oz O, Lu Z, Zhang CC, Kimura W, Sadek HA

Periodical: Nature(2017) (PDF)

Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation

Authors: Liu X, Zhang Y, Ni M, Cao H, Signer RAJ, Li D, Li M, Gu Z, Hu Z, Dickerson KE, Weinberg SE, Chandel NS, DeBerardinis RJ, Zhou F, Shao Z, Xu J

Periodical: Nature Cell Biology(2017) (PDF)

Before 2017

NRF2 regulates serine biosynthesis in non-small cell lung cancer

Authors: DeNicola GM, Chen PH, Mullarky E, Sudderth JA, Hu Z, Wu D, Tang H, Xie Y, Asara JM, Huffman KE, Wistuba II, Minna JD, DeBerardinis RJ, Cantley LC

Periodical: Nature Genetics(2015) (PDF)

Oxidative stress inhibits distant metastasis by human melanoma cells

Authors: Piskounova E, Agathocleous M, Murphy MM, Hu Z, Huddlestun SE, Zhao Z, Leitch AM, Johnson TM, DeBerardinis RJ, Morrison SJ

Periodical: Nature(2015) (PDF)

Inhibition of cancer cell proliferation by PPARγ is mediated by a metabolic switch that increases reactive oxygen species levels

Authors: Srivastava N, Kollipara RK, Singh DK, Sudderth J, Hu Z, Nguyen H, Wang S, Humphries CG, Carstens R, Huffman KE, DeBerardinis RJ, Kittler R

Periodical: Cell Metabolism(2014) (PDF)

Metabonomic profiling of TASTPM transgenic Alzheimer's disease mouse model

Authors: Hu Z, Browne ER, Liu T, Angel TE, Ho PC, Chan EC

Periodical: Journal of Proteome Research(2012) (PDF)