Targeting acetylcholine signaling modulates persistent drug tolerance in EGFR-mutant lung cancer and impedes tumor relapse
Authors: Nie M#, Chen N#, Pang H#, Jiang T#, [...], DeBerardinis RJ, Li W, Yu Q, Zhou C, Hu ZP*
Periodical: Journal of Clinical Investigation(2022) (PDF)
Cancer associated fibroblasts employ NUFIP1-dependent autophagy to secrete nucleosides and support pancreatic tumor growth
Authors: Yuan M, Tu B, Li H, Pang H,[...], Ying H, Zhu WG, Fu D, Hu ZP*, Zhao Y*
Periodical: Nature Cancer(2022) (PDF)
Treatment of SARS-CoV-2 induced pneumonia with NAD+ and NMN in two mouse models
Authors: Jiang Y*,#, Deng Y#, Pang H#, Ma T, Ye Q, Chen Q, Chen H, Hu ZP*, Qin CF*, Xu Z*
Periodical: Cell Discovery(2022) (PDF)
Metabolic characterization of hypertrophic cardiomyopathy in human hearts
Authors: Wang W#, Wang J#,*, Yao K#, Wang S#, Nie M,[...], Yang T, Li P, Song L*, Hu ZP*
Periodical: Nature Cardiovascular Research(2022) (PDF)
Circulatory metabolites trigger ex vivo arterial endothelial cell dysfunction in population chronically
Authors: Cheng W#, Pang H#,[...], Leng S*, Hu ZP*, Tang J*
Periodical: Particle and Fibre Toxicology(2022) (PDF)
Metabolic remodelling during early mouse embryo development
Authors: Jing Zhao#,Ke Yao#,Ling Z#,Yuyan X#,[...],Zeping H*, Jin Zhang*
Periodical: Nature Metabolism(2021) (PDF)
Aberrant NAD+ metabolism underlies ZIKA virus-induced microcephaly
Authors: Pang H#, Jiang Y#, Li J#, Wang Y#, Nie M#, Xiao N, Wang S, Song Z, Ji F, Chang Y, Zheng Y, Yao K, Yao L, Li S, Song L*, Lan X*, Xu Z*, Hu Z*
Periodical: Nature Metabolism(2021) (PDF)
Simultaneous 3-Nitrophenylhydrazine Derivatization Strategy of Carbonyl, Carboxyl and Phosphoryl Submetabolome for LC-MS/MS-Based Targeted Metabolomics with Improved Sensitivity and Coverage
Authors: Meng X#, Pang H#, Sun F, Jin X, Wang B, Yao K, Yao L, Wang L, Liao M, Hu Z*
Periodical: Analytical Chemistry(2021) (PDF)
Integrated cytokine and metabolite analysis reveals immunometabolic reprogramming in COVID-19 patients with therapeutic implications
Authors: Xiao N#, Nie M#, Pang H#, Wang B#, Hu J#, Meng X, Li K, Ran X, Long Q, Deng H, Li S, Chen N, Li S, Tang N*, Huang A*, Hu Z*
Periodical: Nature Communications(2021) (PDF)
Metabolomics, metabolic flux analysis and cancer pharmacology
Authors: Liang L, Sun F, Wang H, Hu Z*
Periodical: Pharmacology & Therapeutics(2021) (PDF)
Mettl17, a regulator of mitochondrial ribosomal RNA modifications, is required for the translation of mitochondrial coding genes
Authors: Shi Z, Xu S, Xing S, Yao K, Zhang L, Xue L, Zhou P, Wang M, Yan G, Yang P, Liu J, Hu Z*, Lan F*
Periodical: The FASEB Journal(2019) (PDF)
Emerging applications of metabolomics in clinical pharmacology
Authors: Pang H, Jia W*, Hu Z*
Periodical: Clinical Pharmacology and Therapeutics(2019) (PDF)
Recent applications of metabolic flux analysis in tumor metabolism
Authors: Li Wen-jie, Hu ze-ping*
Periodical: Chinese Journal of the Frontiers of Medical Science(2019) (PDF)
Metabolic reprogramming and cancer drug resistance
Authors: Yao Li-ang, Hu ze-ping*
Periodical: Chinese Journal of the Frontiers of Medical Science(2019) (PDF)
Arginine deficiency is involved in thrombocytopenia and immunosuppression in Severe Fever with Thrombocytopenia Syndrome
Authors: Li XK, Lu QB, Chen WW, Xu W, Liu R, Zhang SF, Du J, Li H, Yao K,[...],Cao WC*, Hu Z*, Liu W*
Periodical: Science Translational Medicine(2018) (PDF)
Inosine monophosphate dehydrogenase dependence in a subset of small cell lung cancers
Authors: Huang F, Ni M, Chalishazar MD, Huffman KE, Kim J, Cai L, Shi X, Cai F, Zacharias LG, Ireland AS, Li K, Gu W, Kaushik AK, Liu X, Gazdar AF, Oliver TG, Minna JD, Hu Z*, DeBerardinis RJ*
Periodical: Cell Metabolism(2018) (PDF)
Ascorbate regulates haematopoietic stem cell function and suppresses leukaemogenesis
Authors: Agathocleous M, Meacham C, Burgess RJ, Piskounova E, Bruner E, Cowin B, Crane GM, Murphy MM, Hu Z, DeBerardinis RJ, Morrison SJ
Periodical: Nature(2017) (PDF)
CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells
Authors: Kim J, Hu Z, Cai L, Choi E, Rodriguez-Canales J, Villalobos P, Lin YF, Ni M, Unsal-Kacmaz K, Peña CG, Castrillon DH, Chen BPC, Wistuba I, Minna JD, DeBerardinis RJ
Periodical: Nature(2017) (PDF)
Hypoxia induces heart regeneration in adult mice
Authors: Nakada Y, Canseco DC, Thet S, Abdisalaam S, Asaithamby A, Santos CX, Shah A, Zhang H, Faber JE, Kinter MT, Szweda LI, Xing C, Hu Z, Deberardinis RJ, Schiattarella G, Hill JA, Oz O, Lu Z, Zhang CC, Kimura W, Sadek HA
Periodical: Nature(2017) (PDF)
Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation
Authors: Liu X, Zhang Y, Ni M, Cao H, Signer RAJ, Li D, Li M, Gu Z, Hu Z, Dickerson KE, Weinberg SE, Chandel NS, DeBerardinis RJ, Zhou F, Shao Z, Xu J
Periodical: Nature Cell Biology(2017) (PDF)
NRF2 regulates serine biosynthesis in non-small cell lung cancer
Authors: DeNicola GM, Chen PH, Mullarky E, Sudderth JA, Hu Z, Wu D, Tang H, Xie Y, Asara JM, Huffman KE, Wistuba II, Minna JD, DeBerardinis RJ, Cantley LC
Periodical: Nature Genetics(2015) (PDF)
Oxidative stress inhibits distant metastasis by human melanoma cells
Authors: Piskounova E, Agathocleous M, Murphy MM, Hu Z, Huddlestun SE, Zhao Z, Leitch AM, Johnson TM, DeBerardinis RJ, Morrison SJ
Periodical: Nature(2015) (PDF)
Inhibition of cancer cell proliferation by PPARγ is mediated by a metabolic switch that increases reactive oxygen species levels
Authors: Srivastava N, Kollipara RK, Singh DK, Sudderth J, Hu Z, Nguyen H, Wang S, Humphries CG, Carstens R, Huffman KE, DeBerardinis RJ, Kittler R
Periodical: Cell Metabolism(2014) (PDF)
Metabonomic profiling of TASTPM transgenic Alzheimer's disease mouse model
Authors: Hu Z, Browne ER, Liu T, Angel TE, Ho PC, Chan EC
Periodical: Journal of Proteome Research(2012) (PDF)